Ernest J McEachern Selected Research

hexosaminidase C

1/2020	MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy.
11/2019	Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
1/2017	Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice.
10/2014	Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.

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Ernest J McEachern Research Topics

Disease

5	Tauopathies 01/2020 - 08/2008
3	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 08/2008
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 11/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2019
1	Neoplasms (Cancer) 02/2015
1	Cognitive Dysfunction 10/2014
1	Amyloid Plaque 10/2014

Drug/Important Bio-Agent (IBA)

4	hexosaminidase CIBA 01/2020 - 10/2014
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2017 - 08/2008
1	tau Proteins (tau Protein)IBA 01/2020
1	EnzymesIBA 02/2015
1	Lactic Acid (Lactate)FDA LinkGeneric 02/2015
1	Pharmaceutical PreparationsIBA 02/2015
1	Glucose (Dextrose)FDA LinkGeneric 02/2015
1	AcetylglucosamineIBA 10/2014
1	Amyloid (Amyloid Fibrils)IBA 10/2014
1	Peptides (Polypeptides)IBA 10/2014
1	Proteins (Proteins, Gene)FDA Link 10/2014
1	tetra-4-amidinophenoxypropane (TAPP)IBA 10/2014

Therapy/Procedure

1	Therapeutics 02/2015